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Squamous Cell Carcinoma

Squamous cell carcinoma (SCC) is a malignant tumor of the squamous layer of cells of the epidermis, showing keratinocyte differentiation. It is the second most common malignancy affecting the eyelid skin, accounting for 5-10% of such lesions. The majority of SCCs arise from preexisting lesions such as actinic keratosis, Bowen disease, radiation dermatoses, burn scars, and chronic inflammatory lesions. Clinically, SCC appears as a slowly enlarging, flesh-colored or erythematous, nodule or hyperkeratotic lesion with an indurated border and a central ulcer bed often covered with a thick crust or scale, which may bleed easily. Neglected lesions may become more infiltrated and ulcerated with a heaped-up rim.  

Nodular squamous cell carcinoma of the upper eyelid
Infiltrating and ulcerated squamous cell carcinoma involving teh medial canthus and upper and lower eyelids
Massive conjunctival squamous cell carcinoma filling the palpebral fissure and anterior orbit
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